Solubility of Salicylic Acid in Some (Ethanol + Water) Mixtures at Different Temperatures: Determination, Correlation, Thermodynamics and Preferential Solvation
نویسندگان
چکیده
Abstract Equilibrium mole fraction solubility of salicylic acid in nine aqueous-ethanolic mixtures, as well neat water and ethanol, was determined at seven temperatures from T = (293.15 to 323.15) K. Salicylic these mixtures adequately correlated with well-known correlation/prediction methods based on Jouyban-Acree model. Apparent thermodynamic quantities, i.e. Gibbs energy, enthalpy, entropy, for the dissolution mixing processes, were computed by means van’t Hoff equations. The enthalpy–entropy compensation plot enthalpy vs. energy not linear exhibiting positive slopes mixture w 1 0.30 0.50 ethanol indicating enthalpy-driven drug transfer processes but negative interval < entropy-driven more polar less solvent systems. Moreover, using inverse Kirkwood–Buff integrals it is observed that preferentially solvated molecules water-rich those 0.24 x 1.00.
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ژورنال
عنوان ژورنال: International Journal of Thermophysics
سال: 2023
ISSN: ['1572-9567', '0195-928X']
DOI: https://doi.org/10.1007/s10765-023-03224-z